The growing conflict between Israel and Iran has disrupted international air travel in the Middle East, and Central Asia is grappling with cancellations and rerouted flights to and from the region.

Flynas, a low-cost Saudi airline, and Qeshm Air, an Iranian carrier, have temporarily canceled flights to Uzbekistan “due to the escalation of tensions in the Middle East and the closure of part of the airspace,” the state-run Uzbekistan Airports company said on Telegram on Wednesday.

The cancellations were a Flynas flight on the Jeddah-Tashkent-Jeddah route; another roundtrip Flynas flight from Jeddah to the Uzbek city of Namangan and back; and a Qeshm Air flight from Tehran to Tashkent and back to the Iranian capital, according to the Uzbek company. It advised travelers to check departure information with airline representatives.

Air Astana, Kazakhstan’s national carrier, said it had decided to bypass Iran’s airspace on its flights to Dubai after analyzing the situation in the Middle East and following guidance from the national aviation authorities.

“As a result, the flight routes from Astana and Almaty to Dubai will be altered, and flight time will be extended,” Air Astana said on Telegram. “Flights to Jeddah will remain unchanged but may be reconsidered if military activity in the region escalates. If necessary, the airline will implement additional changes to ensure flight safety.”

Aviation authorities of Kazakhstan’s Ministry of Transport have advised domestic airlines to avoid Iranian airspace, according to Kazinform, a state-run news agency.

The flight disruptions came after Iran launched hundreds of missiles at Israel on Tuesday, and Israel warned that it will respond forcefully to the attack. The confrontation threatens a broader conflict in the region as Israel is already conducting military operations against two Iran-backed groups, Hamas in Gaza and Hezbollah in Lebanon.